Advances in antiretroviral therapy have increased life expectancy for people living with HIV (PLWH), but aging exacerbates symptoms such as frailty, neurocognitive disorders, and bone loss. Pharmacological treatments often present limitations, including side effects and drug interactions. Non-pharmacological approaches like physical activity and diet may offer holistic symptom management, yet remain understudied in PLWH. The aim of this study is to investigate the association between physical activity levels, diet quality, and symptom experiences in older PLWH. We will analyze data from the PROSPER-HIV study, a prospective observational study of 850 participants (over 50% aged ≥50 years) from the Center for AIDS Research Network of Integrated Clinical Systems (CNICS) across four U.S. sites. Key measures include: (a) moderate-to-vigorous physical activity, assessed via accelerometry; (b) diet quality, measured by the Healthy Eating Index-2015 (HEI-2015) from 24-hour dietary recall; (c) symptom burden, evaluated using the 20-item HIV Symptom Index; (d) muscle strength, assessed via handgrip strength; and (e) physical function, measured using the Short Physical Performance Battery (timed walk, chair stands, and balance tests). Descriptive analyses will identify patterns in physical activity, diet quality, symptom burden, muscle strength, and physical function collected at baseline. Linear regression models will examine relationships between symptom burden, physical activity, and diet, adjusting for age, sex, muscle strength, and function. Findings will clarify the impact of lifestyle factors on symptoms, supporting the integration of non-pharmacological strategies into nursing care. The results will inform nursing practice and public health by highlighting the role of physical activity and dietary improvements in symptom relief.

Advancements in antiretroviral therapy research are leading to longer life expectancy for people living with HIV (PLWH). Aging is a process that happens with every individual, involving changes in the physical and mental state. However, age-associated symptoms typically occur earlier in these individuals as the disease’s chronic inflammation accelerates the aging process, decrementing PLWH’s lifestyles. Some of the symptoms include fatigue, slower walking speeds, and balance problems. Previous studies prove that exercise is a non-pharmacological method used to improve physical function and wellbeing. Exercise performed at a higher intensity is known to enhance the overall health state of PLWH and generate positive effects on cardiovascular health. The aim of the study is to compare the effects of different exercise intensities on the symptom experience of PLWH. The HEALTH Study is an exercise trial conducted by the University of Washington and the University of Colorado for 120 PLWH aged 50 years or older who reports symptoms of aging and have a sedentary lifestyle. After enrollment, HEALTH Study participants are randomized to either a High-Intensity Interval Training or Continuous Moderate Exercise program lasting for 16 weeks. Participants exercise three times a week in a research center while supervised by trainers. During the study, participants complete many assessments to monitor their physical function and fatigue. The outcome for this study utilizes the HIV symptom index score, collected at baseline (week 0) and post-intervention (week 16). This index score is a 20-question survey that assesses the severity of HIV symptoms, categorized by presence and severity ratings. The end goal of the research is to explore how exercise training can change the symptoms occurring in people living and aging with HIV, creating a strategy for more individuals with HIV to live longer and healthier lifestyles.