Despite advances in treatment regimens for people living with HIV (PLWH), structural factors like food insecurity and housing inaccessibility continue to impact the populations’ health outcomes. As effective treatments, such as antiretroviral therapy (ART), improve health outcomes of PLWH, a new demographic of aging PLWH emerges. Older PLWH balance typical aging conditions like fragility and inflammation buildup with ART polypharmacy adherence within a complex system of social determinants of health (SDOH). SDOH are societal-driven conditions that impact prospective health outcomes such as race, socioeconomic status, access to adequate, nutritious food and shelter. Food security or the consistent access to sufficient, affordable, and healthy food is an upstream factor that greatly influences inflammation. Specific diet patterns such as high-carb and fat diets can also increase inflammation, in turn affecting health outcomes for aging PLWH. Inflammation induces negative side effects for aging PLWH on ART. Using the data collected from the four-year prospective PROSPER-HIV study, we assess the impact of food insecurity and inflammation on PLWH. We evaluate food insecurity using self-reported questions regarding food access scaled on a 5-point Likert scale. In addition, we assess diet-associated inflammation through a dietitian-led food recall. We hypothesize a strong correlation between food insecurity and aging. We expect the results to show how systemic factors significantly impact the health outcomes of PLWH. The findings have implications for policy development and resource needs for marginalized communities facing food insecurity. Uplifting marginalized communities occurs by identifying research gaps and implementing system-wide policies that address those shortcomings to diminish health disparities and promote health equity.

With advancements in antiretroviral therapy (ART), the prevalence of older people living with HIV (PLWH) continues to rise. Accompanying this increase in life expectancy among PLWH, there has also been subsequent evolving symptomatology. These include an increased burden of age-related comorbidities such as increased fatigue, frailty (i.e., muscle shrinking, weakness, slowness, poor endurance), and a lower sense of perceived well-being (e.g., poor mental health, depression, self-image). Research has demonstrated that physical activity (PA) can reduce some of these symptomatologies, especially those related to physical health. However, the implications of using PA to prevent the evolving symptomatologies of older PLWH are still yet to be explored. This study examines the variability of exercise training responses between men and women with HIV. The study considers multiple scalable data and measurements (e.g., Short Physical Performance Battery, fried frailty criteria, patient health questionnaire-9). Using descriptive analysis, this study provides further insight into the impacts of exercise response for PLWH based on Sex. Sex is likely to influence the physical functioning of PLWH. Data was obtained from the High-Intensity Exercise Study to Attenuate Limitations and Train Habits in Older Adults with HIV (HEALTH). This ongoing study incorporates exercise and biobehavioral coaching interventions to determine the efficacy of high-intensity interval training (HIIT) in older PLWH. The HEALTH study involves a randomized trial of 100 older PLWH (≥ 50 years of age) who self-report fatigue and a sedentary lifestyle. Due to the current limitation of sample sizes, the study has been considered with respect to sex-based analyses in the general population. Results of the study is expected to indicate differences in the physical and mental benefits of exercise comparing sex.