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Office of Undergraduate Research Home » 2018 Undergraduate Research Symposium Schedules

Found 1 project

Poster Presentation 3

2:30 PM to 4:00 PM
Towards Deep Brain Monitoring with Superficial EEG Sensors Plus Neuromodulatory Focused Ultrasound
Presenters
  • Lucas Chen, Junior, Pre-Sciences
  • Edward Lou, Senior, Electrical Engineering
  • Madison Lee Selby, Sophomore, Pre Engineering
Mentor
  • Pierre Mourad, Neurological Surgery
Session
    Poster Session 3
  • MGH 241
  • Easel #150
  • 2:30 PM to 4:00 PM

  • Other Neurological Surgery mentored projects (5)
  • Other students mentored by Pierre Mourad (1)
Towards Deep Brain Monitoring with Superficial EEG Sensors Plus Neuromodulatory Focused Ultrasoundclose

Electroencephalograms (EEG’s) are a common form of measuring electrical activity in the brain. Electrical activity from the brain directly correlates to neuronal activity, providing information that can be used for disease diagnosis or research on brain mechanisms. EEG recordings are limited in practicality and efficiency in some circumstances due to poor spatial resolution, vulnerability to noise, and consistency. Subdermal electrodes are unable to capture deep brain activity, which can only be obtained through surgically implanted intracranial electrodes. As a result, for patients in a condition where surgery is not optimal, the subdermal EEG offers little to no information in terms of deep brain activity. Through previous work, we have shown that applying 1050 Hz pulsed focused ultrasound (pFU) resulted in EEG readings above normal physiological frequencies. Natural brain activity frequencies can be derived from the amplitude demodulation of the 1050 Hz signal. The ultrasound is amplifying the electrical activity in the region it is focused upon, allowing the EEG to record these signals. In this study, we attempted to increase the capabilities and specificity of EEG noninvasively through coupling it with pFU. We continued our previous work by applying pFU transcranially to the left visual cortex of a C57BL/6J mouse brain while stimulating the right eye with light. The observed frequencies collected by EEG were analyzed for neuronal stimulation in addition to sensory stimulation elicited from the ultrasound. A technological breakthrough in this field may someday lead to the ability to measure brain activity non-invasively from anywhere in the brain.


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